The 9^th International Conference on
Chemistry, Structure and Function of Biomolecules

Institute of Bioorganic Chemistry, NAS of Belarus

26-29 May 2026 | Minsk, Belarus + Online

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Graphical Abstracts

Plenary Lectures

How many tests are enough to get (more) safe drugs and supplements?

Suzana Jovanović-Šanta, Michail Shapira, Sofija Bekić, Maja Marinović, Sergey Usanov, Yaraslau Dzichenka

Quantum chemical insight into the purine recognition and activation in the catalytic site of E. coli PNP and the regio-selectivity of glycoside bond formation

Igor Mikhailopulo

Oral Session 2

Enzymatic synthesis of modified N⁶-substituted 2-chloro-3'-deoxyadenosines

Еkaterina Zorina, Maria Berzina, Аlexey Kayushin, Irina Konstantinova

Ionic strength as a determining factor of Dopamine-DNA complex formation parameters

Gaspar Kocharyan, Marine Parsadanyan, Anna Nikolyan, Poghos Vardevanyan

Synthesis and study of new biocidal materials based on polyhexamethylene guanidine for water purification

Inna Kholoshenko, Sofia Chepurnova, Peter Shkinev, Fedor Drozdov, Aziz Muzafarov

Oral Session 3

PAMAM-Calix[4]arene dendrimers: spectral, colloidal and supramolecular properties

Tatiana Kopylets, Olga Mostovaya, Igor Shiabiev, Pavel Padnya, Ivan Stoikov

Glutamine prevents hepatic lipid accumulation by modulating lipolysis and oxidative stress

Xiandan Chen, Aliaksei Sysa

Enzymatic synthesis and molecular docking studies of subtituted 5-phenyl-1,2,4-triazole-3-thione deoxyribosides

Ilya Fateev, Sobirdjan Sasmakov, Abdukhakim Ziyaev, Jaloliddin Abdurakhmanov, Olga Smirnova, Maria Kostromina, Alexey Kayushin, Konstantin Antonov, Valeria Andronova, Roman Esipov, Shakhnoz Azimova, Anatoly Miroshnikov, Irina Konstantinova

Effects of C2 and C6 substituents on cytotoxicity of purine nucleosides

Maria Simonova, Maria Berzina, Alexandra Arnautova

Synthesis of new purine substituted 3'-fluoro-3'-deoxy-D-ribonucleosides from D-xylose

Grigorii Sivets

A diterpenoid of the medicinal plant Andrographis paniculata targets vanilloid site of TRPV3 channel and relieves itch

Aleksandr Kalinovskii, Yaroslav Andreev

Pyruvamide 4-allylthiosemicarbazones and their 3d metal complexes: synthesis, structural characterization, and biological evaluation

Natural phytoestrogen ferutinin can form transient pores in lipid membranes in the presence of Mg²⁺- and Ca²⁺-ions

Zaret Denieva, Alexander Firsov, Ljudmila Khailova, Sergey Akimov, Elena Kotova, Oleg Batishchev, Yuri Antonenko

Poster Session 1 (BO)

The effect of the tetrapeptide N-Ac-DSer-PRG-NH₂ on learning in rats in the postnatal valproate-induced model of autism spectrum disorder

Anna Stakhanova, Kseniya Baradzina, Olga Voskresenskaya

Synthesis of a conjugate of meso-arylporphyrin with a transketolase inhibitor

Elizaveta Bon, Alexey Usanyov, Nadezhda Prokopova, Natal'ya Bragina, Kseniya Zhdanova

Synthesis of 2',3'-acyclic analogues of nucleosides by using solid phase reagents based on ion exchange resins

Anna Borschevskaya, Igor Prokhorenko, Irina Konstantinova

Effect of steam sterilization on hyaluronic acid degradation in physiological and hypertonic saline solutions

Alesya Dmitrochenko, Aleksei Yantsevich

Synthesis of fluoroquinolone antibiotic derivatives and their use for the development and study of a direct enzyme-linked immunosorbent assay system

Ludmila Dubovskaya, Olga Kuprienko, Hanna Zilberman, Oleg Sviridov

Synthesis of C-terminally modified oligopeptides bearing aldehyde and ketone functionalities as potential proteases inhibitors

Eugene Ermola, Katsiaryna Kasabutskaya, Dmitry Lisouski, Olga Griboyskaya

Carbohydrate-containing targeted lipoconjugates for gene delivery into eukaryotic cells

Elizaveta Eshtukova-Shcheglova, Elena Shmendel, Mikhail Maslov

Screening of steroid derivatives as potential ligands of human cytochrome P450 27A1

Darya Girko, Yaraslau Dzichenka, Ljubica Grbović, Marina Savić, Jovana Ajduković, Sergei Usanov, Suzana Jovanović-Šanta

Multi-scale investigation of the photochemical properties of rhodopsin from Hymenobacter psoromatis (HbR1): theoretical and experimental study

Daniil Fedotov, Amir Taldaev,Eliza Karapetyants, Alexandra Limonova, Vladislav Pavlov, Egor Zinovev, Ivan Okhrimenko

Steroid–BSA conjugates enabling immunoanalytical differentiation of isomeric B-ring lactones of brassinosteroids

Alexandra Kashaeva, Alina Sauchuk, Vladimir Zhabinskii, Vladimir Khripach

Synthesis and biological testing of conjugates of 2-chloroadenosine derivative with 4-aryl-1,2,3-triazoles

Maksim Khancheuski, Grigorii Sivets

Enzymatic synthesis of new 3’-deoxyribonucleosides derivatives of 1,2,4-triazole-3-carboxamides

Еkaterina Kharlamova, Еkaterina Zorina, Аlexey Kayushin, Anna Baculina

Synthesis of porphyrins sensitizers with light-harvesting function mimicking photosynthesis

Margarita Shagabaeva, Nadejda Konovalova

Synthesis of 6 and 2-heterocyclic substituted purine 3'-deoxy-D-ribonucleosides

Darya Kozlovich, Grigorii Sivets

Сlick chemistry in the synthesis of stable immunoreactive conjugates of hydroxylated haptens with peroxidase

Olga Kuprienko, Alaksiej Hurski, Irina Shirochina, Anastasija Kosmach, Victoryia Lapina, Anna Zilberman, Irina Vashkevich, Oleg Sviridov

Aryl-modified indirubin-glutathione conjugates with different linker chemistry as inhibitors of glutathione transferase isoforms P1a and P1b

Sofiya Kuzmenka, Syargey Gilevich

Salicylic acid derivatives containing aliphatic-chain hydroxamates: synthesis and cytotoxic activity against HepG2 cell line

Maryna Lisouskaya, Valeryia Laptsevich

Growth-promoting effect of brassinosteroids in composition with the bacteria Priestia megaterium cp-1 and Rhodococcus jostii ca-6

Raisa Litvinovskaya, Alina Sauchuk, Vladimir Khripach, Nadezhda Naumovich, Irina Ananyeva, Zinaida Aleshchenkova

The effect of the EPIN-succinic acid biocomposition on the productivity of spring wheat

Raisa Litvinovskaya, Nelli Manzhalesava, Alina Sauchuk, Inna Bruy, Vladimir Khripach

A novel route to Alexa Fluor 488 for bioconjugation applications

Danila Makolski, Alena Blizniuk, Egor Ulashchik, Vadim Shmanai

Analysis of the reaction of Gossypol with 2-Aminobenzoic acid in various solvent media

Zuxrobov Ravshanbek, Bakhtiyar Ibragimov, Jalil Qodirov, Azimjon Mamadrahimov, Felix Pashkovsky, Dmitry Rubinov, Fedor Lakhvich

Solubilization of fatty acids ethanolamides. Solving the problem bioavailability/bioefficiency

Alexander Mikhal’chuk

Nucleoside analogues with pyrazole heterocyclic bases

Anton Mironov, George Dolgopolov, Barbara Eletskaya, Elena Matyugina

Synthesis of conjugates of cationic porphyrin and erlotinib with gold nanoparticles

Anna Notarova, Yulia Bortnevskaya, Natal'ya Bragina, Kseniya Zhdanova

Mannosylated targeted lipoconjugates for gene therapy

Ekaterina Prokopeva, Elizaveta Eshtukova-Shcheglova, Mikhail Maslov

A novel rhodamine-derived fluorescent chemosensor for selective fructose quantification

Bahdan Ranishenka, Tatsiana Seviarynchyk, Andrei Bekish, Aliaksei Kadutskii, Sergey Moroz, Vadim Shmanai

One-pot synthesis of a novel Cu(II) complex based on 2,6-diacetylpyridine dihydrazone and salicylaldehyde

Marijana Regojević, Milica Bogdanović, Ivana Borišev, Vukadin Leovac, Mirjana Radanović

The effect of Tweens on lipid nanoparticles colloidal properties

Yahor Samailovich, Aliaksei Flerko, Maksim Fomich, Olga Sharko, Vadim Shmanai

The effect of brassinosteroids and succinic acid on the content of endogenous phytohormonal steroids

Alina Sauchuk, Raisa Litvinovskaya, Nelli Manzhalesava, Vladimir Khripach

Photochemical reduction of human cytochromes P450 adsorbed on TiO₂ surface

Artem Semynin, Yaraslau Dzichenka, Natallia Babaryka

Synthesis of novel natural chlorin derivatives bearing secondary amines and their antimicrobial activity

Margarita Shagabaeva, Nikita Suvorov, Alexey Noev, Viktoria Shchelkova, Alexander Popov, Sergey Tikhonov, Viktor Pogorilyy, Nadezhda Konovalova, Yuri Vasil’ev, Mikhail Grin

A new synthesis of 2-salicylates of epicastasterone and epibrassinolide

Alina Trifonova, Maxim Leonchuk, Olesya Panibrat, Vladimir Zhabinskii, Vladimir Khripach

Salicylates of stigmastane series (22S,23S)-brassinosteroids: synthesis and biological activity

Alina Trifonova, Maxim Leonchuk, Olesya Panibrat, Vladimir Zhabinskii, Vladimir Khripach

Polysaccharides from aquaculture as a platform for synthesis of macromolecular antioxidants

Mikhail Torlopov, Elena Udoratina

Use of recombinant nucleoside phosphorylases in the synthesis of new structural analogues of ribavirin

Kira Uranskaya, Olga Smirnova, Alexey Kayushin, Irina Konstantinova

Approaches to determining tetracycline antibiotics using tetracycline-binding proteins

Irina Vashkevich, Olga Kuprienko, Anna Zilberman, Viktoria Lapina, Irina Shirochina, Oksana Vinnikova, Dmitry Semenov, Irina Horbachova, Oleg Sviridov

Engineering a high-expression truncated terminal deoxynucleotidyl transferase

Tatiana Zarihta, Antos Sachanka

Plenary Lectures

Design, synthesis, and activity evaluation of novel herbicide safeners derived from the natural product quinine

Zhen X. Xu, Fei Ye, Ying Fu

New ways to make privileged heterocyclic scaffolds using N-O bond chemistry

Alexey Sukhorukov

Versatile BODIPY dyes: design, synthesis, and intracellular bioimaging

Oral Session 4

Design, synthesis, and herbicidal evaluation of novel ester-functionalized N‑phenylphthalimide derivatives containing pyridine as protoporphyrinogen IX oxidase inhibitors

Li-xia Zhao, Hao Zhang, Shuang Gao, Ying Fu, Fei Ye

Gemini amphiphiles derived from monoterpenoids: membrane perturbation and antimicrobial activity

Yulia Panina, Alan Akhmedov, Rustem Gamirov, Alina Baklagina, Anastasiya Gorlankina, Dmitry Shurpik, Ivan Stoikov

Sydnone imine derivatives with lipoic acid: synthesis, evaluation and comparison of biological activity

Angelina Shulgina, Vasily Shchelkonogov, Olga Baranova, Veronika Derevyago, Ilya Cherepanov, Natalya Kalganova

Preparation of 2-amino-3-cyano-4H-chromene derivatives by multicomponent reactions and the dependence of antibacterial properties in vitro on the introduced functional groups

Dzianis Misiulia, Iryna Myneyeva

Search for synthetic rutes to key derivatives for the preparation of triazole-containing peptidomimetics

Mariia Kniazeva, Denis Prokhorov

Innovative antibacterial coatings based on organosilicon derivatives of QACs

Marina Shagidanova, Peter Shkinev, Fedor Drozdov, Aziz Muzafarov

Phytol based bis-amphiphiles for microbial flocculation and water purification

Rustem Gamirov, Alan Akhmedov, YuliaPanina, Dmitriy Shurpik, Ivan Stoikov

Novel benzo[1,2-d:3,4-d']diisoxazoles and their saturated analogs as anticancer agents: design, synthesis and biological evaluation

Nastassia Varabyeva, Yauheni Astrouski, Tatyana Chukarina, Svetlana Ogurtsova, Fedor Lakhvich, Yuri Piven

Anion-controlled metal-free regioselective arylation reactions

Yana Safinskaya, Mikhail Il'in, Dmitry Bolotin

Oral Session 5

Non-viral systems based on dendronized thiacalix[4]arenes for siRNA delivery

Igor Shiabiev, Pavel Padnya, Dmitry Pysin, Alesia Stanavaya, Viktar Abashkin, Bahdan Ranishenka, Dzmitry Shcharbin, Ivan Stoikov

Dioximes as convenient building blocks in the synthesis of nitrogen heterocycles

Evgeny Pospelov, Alexey Sukhorukov

Enhanced vinylation protocols using in situ generated acetylene for efficient synthesis of vinyl ethers

Vladimir Voronin_, Maria Ledovskaya

Poly(propyleneimine) dendrimers based on thiacalixarene: synthesis, cytotoxicity, and 5‑fluorouracil binding

Pavel Padnya, Igor Shiabiev, Dmitry Pysin, Anastasia Nazarova, Alesia Stanavaya, Viktar Abashkin, Bahdan Ranishenka, Dzmitry Shcharbin, Ivan Stoikov

Macrocyclic terpenoids based on pillar[5]arene: synthesis, supramolecular self-assembly, and biological activity

Alan Akhmedov, Rustem Gamirov, Yulia Panina, Evgenia Subakaeva, Dmitriy Shurpik, Ivan Stoikov

Calcium carbide as a source of C₂ unit for the synthesis of organic building blocks and heterocycles construction

Maria Ledovskaya, Vladimir Voronin

Adaptive dynamic homogeneous Ni catalysis for derivatization of drugs and natural compounds

Indrajit Ghosh, Nikita Shlapakov, Valentine Ananikov, Burkhard König

Poster Session 2 (O)

Synthesis of novel polynitrogen fused 5-arylisoxazolylchromenes

Irina Kolesnik, Ekaterina Akishina, Artsiom Khadarovich, Anastasia Duboiskaya, Yury Kornoushenko, Alexander Andrianov, Vladimir Potkin

Synthesis of hydrophilic fluorescein derivatives for bioimaging

Aleksey Kadutskii, Alex Arol,Vadim Shmanai, Tatsiana Asiyevskaya-Akhlamionak

Total synthesis of (–)-bipolarolide D

Gleb Chesnokov, Julia Friedli, Francis Carta, Karl Gademann

Low dose rate effect on radiation-induced fragmentation of α-diols: kinetic modeling

Volha Ekenel, Roman Sverdlov, Anastasia Sladkova, Henrietta Nichipor

L-Hydroxyprolinol‑based cyanine reagents enabling efficient synthesis of fluorescently labeled oligonucleotides

Margarita Pilicheva, Margarita Rebkavets, Maksim Fomich, Vadim Shmanai

Synthesis of new hydrazono-hydrazide androstane derivatives as potential glucocorticoid receptor ligands

Đorđe Janković, Sofija Bekić, Maja Marinović, Anđelka Ćelić, Edward Petri, Marina Savić, Jovana Ajduković

Ion exchange in alginate hydrogel carriers as a method to enhance drug retention

Vladislav Kaplin, Anastasiia Kuryanova, Nikolay Glagolev, Tatyana Zarkhina, Yuri Gordienko, Anna Solovieva

Photochemical radical ring-opening alkylation of cyclopropanols with katritzky salts

Ulada Karotsina, Kirill Stasko, Vitaly Syakhovich, Ivan Lysenko, Alaksiej Hurski

Design, synthesis and bioevaluation of novel 3-aroylpyridine-2,4(1H,3H)-diones as 4-hydroxyphenylpyruvate dioxygenase inhibitors

Tatyana Khlebnicova, Dmitry Rubinov, Veronica Zinovich, Yue Li, Fedor Lakhvich, Ying Fu, Fei Ye

Synthesis of new 2-substituted 5-ethynyltetrazole

Danila Leonkov, Dmitriy Kopachev, Alexandr Zuraev

Ribbed functionalization of an iron(II) bis-α-benzyldioximate dichloroclathrochelate with S-nucleophiles containing the biorelevant (amine or carboxyl) substituent(s): synthesis, structure and in vitro biotesting

Ilya Limarev, Yan Voloshin

The role of tetrazole fragments in the formation of supramolecular systems based on pillar[5]arenes: from drug delivery systems to electrochemical sensors

Lyaysan Makhmutova, Elina Badykova, Dmitriy Shurpik, Adel Guseinova, Rezeda Shamagsumova, Ivan Stoikov

Biologically active acyl derivatives of the alkaloid salsoline

Ekaterina Margun, Evgeniy Dikusar, Gulim Mukusheva, Aikerim Olzhabaeva, Gulzhaukhar Toktarbay, Roza Seidakhmetova

tert-Butylmagnesium chloride: homogeneous sacrificial reductant for the fast nickel-catalyzed cross-electrophile coupling of alkyl and aryl iodides

Artyom Mikhaliov, Kirill Stasko, Anton Kasich, Mikita Tsiuryn, Vitaly Syakhovich, Alexander Lugovski, Vladimir Dolgopalets, Alaksiej Hurski

Self-assembly of pillar[5]arene with herbicides for tuning phytotoxicity and environmental impact

Anastasia Nazarova, Vildan Sultanaev, Polina Kuryntseva, Svetlana Selivanovskaya, Pavel Padnya, Ivan Stoikov

Synthesis of isoxazolo- and isoxazoline derivatives of gossypol as new potential antimicrobial, antiviral and antitumor agents

Felix Pashkovsky, Dmitry Rubinov, Vladislav Linnik, Fedor Lakhvich, Ravshanbek Zuhrobov, Bakhtiyar Ibragimov, Azimjon Mamadrahimov

Synthesis of carboranyl azides as key intermediates for “click” reaction with acetylenic steroids

Mikhail Petrov, Angelina Telegina, Maria Borisenko, Vladimir Zhabinskii, Vladimir Khripach

Synthesis of novel cholesterol–carborane conjugates

Mikhail Petrov, Angelina Telegina, Vladimir Zhabinskii, Vladimir Khripach

Synthesis of MitoTracker Deep Red and its Cy3–Cy7.5 analogues

Margarita Pilicheva, Beatrisa Rimskaya, Vadim Shmanai

Stereoselective synthesis of functionalized perhydropyrrolo[1,2-b]isoxazoles based on (3+2)-annulation of donor–acceptor cyclopropanes and isoxazolines

Konstantin Potapov, Maxim Novikov, Roman Novikov, Yury Tomilov

Synthesis of Z-11-tetradecenol and its acyl derivatives by using the Wittig reaction

Gulnara Shakirzyanova, Omonkul Kholbekov, Svetlana Boyko, Marina Nemkevich, Ulugbek Togaev

Dipolar cycloaddition of terminal olefins to nitrile oxides generated from tertiary alcohols bearing secondary nitro group

Siarhei Shepialevich, Alexander Baranovsky, Peter Kurman

Photocatalytic reaction of hydroxycyclopropanes with vinyltriphenylphosphonium bromide as a synthetic route to 1,4-substituted cyclopentenes

Siarhei Shepialevich, Artyom Mikhaliov

Synthesis of new amino and cyano estradiol analogs

Sergey Sokolov, Alexander Baranovsky

Plenary Lectures

Beyond animal serum: sustainable biomolecules for cell culture

Marija Stojadinović

Oral Session 7

Novel hydroxamic acid derivatives as promising HDAC6 inhibitors with neuroprotective effect

Evgenii Borisenko, Anastasia Kunitsyna

Identification of secreted form of thioredoxin in culture fluid of antagonistic strain Bacillus subtilis VIZR M22

Joseph Mikhel, Anna Barashkova, Eugene Rogozhin

Tetranitrosyl iron complexes with thiophenol derivatives: interaction with mucin

Veronika Novikova, Karina Ruina, Olesya Pokidova, Nataliya Sanina

Making the invisible visible: determination of biologically active compounds with low UV-activity by capillary electrophoresis

Alexey Shnitko, Nataliya Yaglova, Sergey Obernikhin

New perspective iron-sulfur nitrosyl complex as potential anti-inflammatory agent

Mariia Chicheva, Ludmila Matveeva, Karina Ruina, Veronika Novikova, Olesya Pokidova, Nataliya Sanina

Poster Session 2 (B)

Polysaccharide‑based carriers for anthocyanins: evaluating immobilization efficiency by FTIR spectroscopy

Marharyta Kalbysheuskaya, Varvara Volkova

Ligand-binding properties of recombinant CYP2J2 and in silico PPI screening

Yauheniya Khyuppenen, Maria Kisel, Andrey Svirid

Biocatalytic conversion of Bombyx mori silk sericin into low-molecular-weight peptides: promising modulators of carbohydrate metabolism

Marina Lukyanova, Irina Kiryanova, Olga Gribovskaya

The development of an extracellular expression system for recombinant proteins in Escherichia coli using the osmotically inducible protein

Alina Komyakova, Natalia Shoshina, Vasiliy Stepanenko

Myeloperoxidase and hypochlorous acid as modulators of key innate immunity effectors

Ilia Krenev, Alexey Sokolov, Mikhail Berlov

Effect of crosslinking agent nature on swelling kinetics of alginate hydrogels and antibiotic release rate

Anastasiia Kuryanova, Nikolay Glagolev, Vladislav Kaplin, Victoriya Timofeeva, Anna Solovieva

Antimicrobial activity of the liposomal form of imidocarb dipropionate

Natalya Litvinko, Natalia Pavlyuchenko, Denis Gerlovsky

Protective effect of lactone- and ketone-containing brassinosteroids for barley plants under water deficit

Elena Danilova, Daria Melnik, Liliya Kolomeichuk, Raisa Litvinovskaya, Vladimir Khripach, Marina Efimova

Chemical element profile and biological activity of aqueous and aqueous-alcoholic extracts of different layers of the birch mushroom chaga (Inonotus obliquus)

Liliya Nadolnik, Vyacheslav Polubok, Alexey Shuriberko, Anna Marchik, Tatiana Borodina

Effect of solvents on the stability of the nitrosyl iron complex with methylthiosalicylate

Karina Ruina, Veronika Novikova, Olesya Pokidova, Nataliya Sanina

Overexpression and purification of human angiogenesis regulators VEGF165 and ANGPT1 in Escherichia coli

Antos Sachanka, Ekaterina Popicheva, Aliaksei Yantsevich

Low molecular weight antigen derivatives for oligonucleotide labeling and immunodetection of DNA amplicons in multiplex assay for pathogenic bacteria

Tatyana Serchenya, Victoryia Lapina, Egor Ulashchik, Palina Baryshchyk, Olga Kuprienko, Vadim Shmanai, Oleg Sviridov

Evaluation of rice samples for the presence of the qDTY6.1 drought tolerance gene using DNA markers RM510 and RM19367

Alexandra Shcherbina, Vladislav Kotsarev

The effect of glucose on the spectral properties of hemoglobin in oxygen-saturated environments

Lidiya Skorostetskaya, Polina Smiyan, Natalia Litvinko

The effect of hydrogen peroxide on the spectral properties of hemoglobin under hypoxic conditions

Lidiya Skorostetskaya, Polina Smiyan, Natalia Litvinko

Intermolecular interactions of human cytosolic sulfotransferases with cytochromes P450

Anastasiya Tumilovich, Evgeniy Yablokov, Oksana Gnedenko, Diana Mednaia, Yuri Mezentsev, Pavel Ershov, Leonid Kaluzhskiy, Tatsiana Tsybruk, Irina Grabovec, Polina Shabunya, Andrei Gilep, Alexis Ivanov

Evaluation of the ability of magnesium ions complexed with lipopolysaccharide to promote complement activation

Tatiana Yakovleva, Ilia Krenev, Nikolay Gorbunov, Valeria Kostevich, Nikita Oborin, Galina Aleshina, Mikhail Berlov

Oral Session 1

Information system for early safety assessment of new pharmacological substances

Polina Savosina, Dmitry Druzhilovskiy

Virtual screening of influenza A virus inhibitors targeting the hemagglutinin stem region

Frants Konstantinov, Viktor Urban, Valery Veresov

Conformational dynamics of the β1–β2 loop in Solanum tuberosum translation initiation factor 4E and its mutant forms as a marker of the ability to bind PVY VPg

Ekaterina Nikonova, Vladimir Andreitsev, Victoria Kolesnikova, Alisa Mikhaylina, Oleg Nikonov

Poster Session 1 (INF)

Virtual screening of the DrugBank database using molecular docking methods to identify potential inhibitors of the human Grp94 protein

Lizaveta Dvaraneva, Danila Varabyeu, Sergey Braginets, Alexander Tuzikov, Alexander Andrianov

Transcriptomic dissection of CD34⁺ hematopoietic stem cells to identify niche-specific gene signatures using machine learning

Oloche Celestine Eije

The synthesis and in silico evaluation of affinity with CYP450 of coumarin derivatives

Nikita Eremin, Nina Frolova, Yaroslav Faletrov

Comparing predictive power of molecular docking scoring functions under realistic virtual screening conditions via the CASF-2016 benchmark

Kanstantsin Furs, Yan Laikou, Alexander Tuzikov, Alexander Andrianov

ChemBERTa-based predictive model for identifying novel CYP19A1 ligands

Uladzislau Hlatankou, Yaraslau Dzichenka

Predicting rhodopsin photochemistry to bioprospect new optogenetic tools

Polina Khorn, Daniil Fedotov, Andrei Khnykin, Ekaterina Malysheva, Andrei Pavlov, Arina Anuchina, Matvey Kolesnik, Alina Demkina, Ilya Rubinshtein, Amir Taldaev, Alexey Mishin, Valentin Borshchevskiy

Molecular modeling of point mutations in the glutathione transferase P1b active site

Bozhena Kosareva, Syargey Gilevich, Yaraslau Dzichenka

Surface tension-modifying chaplin proteins in Actinomycetota genomes: results of bioinformatic analysis

Vladislav Kotsarev

Primers for amplification of repeat region in mitochondrial genomes of aphids

Katsiaryna Latyshonak, Sofia Levykina

Comparative in silico mapping of protein-protein interaction hotspots in human cytochromes P450

Anna Savich, Maria Kisel, Andrey Svirid

Design for novel peptide ligands with selectivity for IL-6 and IL-8

Ivan Semkou, Yuri Piven, Olga Gribovskaya

Explainable machine learning to discriminate structural features underlying the inhibition of CYP17A1 17,20 lyase and 17α hydroxylase activities

Marina Shaladonova, Sergey Usanov

Application of in silico drug repurposing strategy for identification of potential inhibitors against the human LPAR1 protein

Alisa Skolysh, Danila Varabyeu, Sergey Braginets, Alexander Tuzikov, Alexander Andrianov

Ga³⁺ as agents of structural destabilization in bacterial metalloproteins

Bogdan Sudakov, Yaraslau Dzichenka

Virtual screening of potential inhibitors against human kynurenine monooxygenase protein

Alena Turpakova, Danila Varabyeu, Sergey Braginets, Alexander Tuzikov, Alexander Andrianov

Oral Session 1

Mechanisms of amyloid-beta molecular interactions with D-peptides

Anastasia Kryuchkova, Eduard Bocharov, Ivan Ohrimenko

Native morphology and composition of large dense core vesicles in adrenergic and noradrenergic neuroendocrine cells by cryo-electron tomography

Zhaohan Lin, Meixuan Ping, Yinglin Li, Xiaolan Yue, Shuang Li, Yuefeng Jiang, Xinlei Ma, Yuqi Hang, Xingyu Du, Bing Liu, Zhe Zhang, Zhuan Zhou, Quanfeng Zhang

Structural elements forming Zn²⁺- and pH- sensitivity in mirror rhodopsins

Daniil Sidorov, Siarhei Bukhalovich, Yury Ryzhykau

DNA condensation by a periodically charged surface at different ionic strength

Evgeniy Dubrovin, Nikolay Barinov, Dmitry Klinov

Quantum chemical study of non-covalent complexes of closo-borate anions [B_nH_n-1X]^y– with alanine dipeptide

Ilya Klyukin, Anastasia Kolbunova, Konstantin Zhzhin

Structural basis for substrate recognition and inhibition of the vesicular acetylcholine transporter enables discovery of selective inhibitors

Yang Zhang, Zhe Zhang

Poster Session 1 (S)

Preparation of chimeric proteins of the translation initiation factors eIF4E and eIF4G Solanum tuberosum for structural studies

Vladimir Andreitsev, Victoria Kolesnikova, Ekaterina Nikonova, Vitaly Balobanov, Oleg Nikonov

Using oligopeptide hydrocarbon monolayer to investigate DNA denaturation on graphite surfaces by AFM

Nikolai Barinov, Evgeniy Dubrovin, Dmitry Klinov

The role of the eIF4E β3‑β4 loop of potato virus Y (PVY) viral protein VPg recognition: kinetic evidence from surface plasmon resonance

Victoria Kolesnikova, Ekaterina Nikonova, Vladimir Andreitsev, Phat T. Do, Natalia Lekontseva, Alisa Mikhaylina, Oleg Nikonov

Overproduction and purification of tomato eIF4E family proteins

Natalia Lekontseva, Victoria Kolesnikova, Alisa Mikhaylina, Phat Tien Do, Ekaterina Nikonova, Oleg Nikonov

Use of the VPg-mCherry chimeric protein to study interaction with the potato translation initiation factor eIF4E in vitro

Ekaterina Nikonova, Victoria Troshchilova, Vladimir Andreitsev, Victoria Kolesnikova, Alisa Mikhaylina, Oleg Nikonov

Oral Session 6

Head-to-head comparison of lentiviral and non-viral mRNA-based anti-CD19 CAR-T cells with clinically validated CD28ζ and 4-1BBζ costimulatory domains: in vitro evaluation and exploratory in vivo studies

Ildus Pateev, Dmitriy Ovcharenko, Olga Bityukova, Ekaterina Minskaia, Ivan Gaponenko, Kirill Lepik, Marina Vasyutina, Olga Vasileva, Ivan Skvortsov, Yana Toropova, Vasiliy Reshetnikov, Maksim Baranov, Roman Ivanov

Study of the effect of oligopeptide V-5 on neuromuscular parameters of C57B1/6 mice under the conditions of the rotarod performance test

Darya Makeyeva, Elena Kravchenko, Natalia Bizunok, Kseniya Borodina, Olga Gribovskaya, Roman Zilberman, Boris Dubovic

Assessment of the impact of amino acids on the rheological properties of hyaluronic acid gel

Vladislav Sepp, Ksenia Ushakova, Konstantin Bakulin, Sandzhi Ubushaev, Vasilii Rusakov, Egor Shchukin

Two-faced Janus: Asymmetric acyclic diaminocarbene Pd complexes as dual-active antiproliferative agents against oxaliplatin-resistant colorectal HCT116 cell line

Tatiyana Serebryanskaya, Olga Gnedina, Maria Igotti, Andrey Kulsha, Oleg Ivashevich, Mikhail Kinzhalov

Ultrafiltration cleaning of the cultured fluid of Coprinopsis lagopides fungus with fibrinolytic properties

The role of a polyelectrolyte complex based on sodium alginate and chitosan in the creation of biocomposites for orthopedics

Olga Golovanova

Antioxidant properties of medicinal plant micellar extracts

Guzel Ziyatdinova, Elizaveta Krasil’nikova

The effect of amphiphilic polymers on the photodynamic activity of methylene blue in vitro and in vivo experiments

Nadezhda Aksenova, Anastasiya Kuryanova, Michael Biryukov, Arif Mekhtiev, Aleksey Fayzullin, Peter Timashev, Anna Solovieva

Poster Session 2 (PH)

Synergy of the antibacterial action of amoxicillin and cobra venom in vitro

Denis Gerlovsky, Anastasia Chaplyuk, Natalia Litvinko, Anastasia Borushkova

Pro-Leu modifies the behavioral effects of the oxytocin receptor antagonist L-368,899 under individual actimetry conditions

Elena Kravchenko, Oksana Savanets, Lyubov Olgomets, Natalia Bizunok

Bioequivalence of Lapatinib film-coated tablets vs Tyverb^®

Andrey Lobov, Alena Konoplich, Anastasia Malyavko, Svetlana Babitskaya, Lyudmila Balashova, Darya Rylko, Alla Samson, Yuri Pokhodnya, Elena Kalinichenko

Antitumor activity and tumor selective uptake of steroid-carborane conjugates

Olesya Panibrat, Alina Trifonova, Angelina Telegina, Vladimir Zhabinskii, Vladimir Khripach

Effect of the synthetic analog of the С-terminal fragment of arginine vasopressin
N-Ac-Trp-Pro-Arg-Gly-NH₂ on mouse behavior in the Pole Test

Oksana Savanets, Elena Kravchenko, Katerina Stepanova, Kseniya Baradzina, Olga Gribovskaya, Roman Zilberman

Effects of the tetrapeptide V-5 under conditions of modeled neurotoxicity induced by 14-fold administration of haloperidol

Katerina Stepanova, Oksana Savanets, Elena Kravchenko, Natalia Bizunok, Kseniya Borodina, Olga Gribovskaya, Roman Zilberman, Ilia Boldusov

Study of the potential effects of a tetrapeptide structurally related to a fragment of semaglutide on metabolic disturbances induced by subchronic administration of haloperidol

Katerina Stepanova, Oksana Savanets, Ilia Boldusov, Ivan Holik, Maria Mamirgova, Elena Kravchenko, Roman Zilberman