Plenary Speakers

Research topics include study of the biological activity of natural and modified steroids in vitro on cell cultures, expressed proteins and animal tissues and in vivo on animal or plant models: testing of antiestrogenic, anticancer, antioxidant andea elicitor activity, measuring the effect on steroid-converting enzymes, using enzymes in the synthesis of novel steroidal compounds and other.

Current research interests cover the chemistry of N-O bond-containing compounds, stereoselective target-oriented synthesis, catalytic domino reactions, click chemistry, and new ligands for high-valent transition metal complexes.

Research interests focus on developing heterosteroidal compounds as anticancer agents against hormone-dependent cancers. This involves the rational design of targeted molecules, the development of efficient synthetic strategies, and the establishment of structure-activity relationships.

My research is focused on the the biochemistry and structural biology of steroid-metabolizing cytochrome P450 enzymes, exploring their substrate specificity, catalytic potential for biocatalysis and inhibition by compounds with potent antiproliferative and proapoptotic effects, for therapeutic applications.

Research focuses on cellular immunotherapy, with particular emphasis on CAR-T cell therapy for hematologic malignancies.
Has contributed to clinical and preclinical studies evaluating CAR-T therapies and immune biomarkers in oncology. His expertise includes flow cytometry, cell culture, genetic analysis, and the development of advanced cellular therapy platforms.

The scientific interests are:

• Design, synthesis and bioassay of agrochemicals;
• Synthesis and Mechanism of Herbicide Safeners;
• Construction of nano drug delivery system.

Research interests:

• the effect of driver genes and essential genes on the transcriptome complexity and robustness in human leukemia and normal immature (early) blood cells;
• splicing code and determinants of splicing process;
• computational transcriptomics;
• proteogenomics;
• high-throughput technologies and multivariate data analysis in multiomics (panomics).

Short description of main research directions:

• organic and bioorganic chemistry
• biotechnology of nucleic acids and nucleotides
• quantum chemical analysis of the heterocyclic bases recognition and activation in the catalytic site of nucleoside phosphorylases and the regio-selectivity of glycoside bond formation.